Effect of the mitral valve on diastolic flow patterns

作者: Jung Hee Seo , Vijay Vedula , Theodore Abraham , Albert C. Lardo , Fady Dawoud

DOI: 10.1063/1.4904094

关键词: VentricleFlow patternMitral valveVentricular functionPhysicsHemodynamicsCardiologyInternal medicineBlood circulationDiastolic flowCirculatory system

摘要: The leaflets of the mitral valve interact with jet and significantly impact diastolic flow patterns, but effect morphology kinematics on its implications for left ventricular function have not been clearly delineated. In present study, we employ computational hemodynamic simulations to understand flow. A model ventricle is constructed based a high-resolution contrast computed-tomography scan, physiological inspired synthesized from morphological echocardiographic data. Simulations are performed diode type as well in order delineate mitral-valve intraventricular study suggests that normal promotes formation circulatory (or “looped”) pattern ventricle. also increase strength apical flow, thereby enhancing washout mixing blood. these findings models discussed.

参考文章(48)
Matteo Astorino, Jeroen Hamers, Shawn C. Shadden, Jean-Frédéric Gerbeau, A robust and efficient valve model based on resistive immersed surfaces. International Journal for Numerical Methods in Biomedical Engineering. ,vol. 28, pp. 937- 959 ,(2012) , 10.1002/CNM.2474
Philip J. Kilner, Guang-Zhong Yang, A. John Wilkes, Raad H. Mohiaddin, David N. Firmin, Magdi H. Yacoub, Asymmetric redirection of flow through the heart Nature. ,vol. 404, pp. 759- 761 ,(2000) , 10.1038/35008075
Jung Hee Seo, Vijay Vedula, Theodore Abraham, Rajat Mittal, MULTIPHYSICS COMPUTATIONAL MODELS FOR CARDIAC FLOW AND VIRTUAL CARDIOGRAPHY International Journal for Numerical Methods in Biomedical Engineering. ,vol. 29, pp. 850- 869 ,(2013) , 10.1002/CNM.2556
Hiroshi Watanabe, Seiryo Sugiura, Hidenobu Kafuku, Toshiaki Hisada, Multiphysics simulation of left ventricular filling dynamics using fluid-structure interaction finite element method. Biophysical Journal. ,vol. 87, pp. 2074- 2085 ,(2004) , 10.1529/BIOPHYSJ.103.035840
Andrew F. Hall, Joseph A. Aronovitz, Scott P. Nudelman, Sándor J. Kovács, Automated method for characterization of diastolic transmitral doppler velocity contours: Early rapid filling Ultrasound in Medicine and Biology. ,vol. 20, pp. 107- 116 ,(1994) , 10.1016/0301-5629(94)90046-9
David M. McQueen, Charles S. Peskin, A three-dimensional computer model of the human heart for studying cardiac fluid dynamics ACM SIGGRAPH Computer Graphics. ,vol. 34, pp. 56- 60 ,(2000) , 10.1145/563788.604453
Jinhee Jeong, Fazle Hussain, On the identification of a vortex Journal of Fluid Mechanics. ,vol. 285, pp. 69- 94 ,(1995) , 10.1017/S0022112095000462
F. DOMENICHINI, G. PEDRIZZETTI, B. BACCANI, Three-dimensional filling flow into a model left ventricle Journal of Fluid Mechanics. ,vol. 539, pp. 179- 198 ,(2005) , 10.1017/S0022112005005550
Bruce Furie, Barbara C. Furie, Mechanisms of Thrombus Formation The New England Journal of Medicine. ,vol. 359, pp. 938- 949 ,(2008) , 10.1056/NEJMRA0801082
Johannes Töger, Mikael Kanski, Marcus Carlsson, Sándor J. Kovács, Gustaf Söderlind, Håkan Arheden, Einar Heiberg, Vortex Ring Formation in the Left Ventricle of the Heart: Analysis by 4D Flow MRI and Lagrangian Coherent Structures. Annals of Biomedical Engineering. ,vol. 40, pp. 2652- 2662 ,(2012) , 10.1007/S10439-012-0615-3