Schizophrenia: from neurophysiological abnormalities to clinical symptoms

摘要: Schizophrenia (SCZ) has long been associated with multifaceted dysfunctions and multiple genetic as well environmental etiological factors (Rethelyi et al., 2013). Therefore, after a century of inconsistent results, the search for unifying pathogenetic mechanism become one most challenging issues in SCZ research. During last decade, growing literature pointed to so-called disconnection hypothesis (Friston, 1998; Tononi Edelman, 2000; Stephan 2009), i.e., defective integration among distributed brain areas, which may lead systematic impairment information processing. EEG is suitable tool probe this time domain, since oscillatory activity can capture subtle functional changes underlying neuronal systems exquisite temporal resolution. Consistent prediction, several recent findings have shown abnormalities neural oscillations during both wakefulness (Uhlhaas Singer, 2014) sleep (Gardner 2014). Cognitive theoretical approaches functioning used explain phenomenological features disruptions SCZ. Since its earliest conceptualizations, self-experience identified critical feature illness (Schneider, 1950). Positive passivity symptoms hypothesized involve misattribution self-generated actions, thoughts percepts an external agency (Frith, 2005). One possible neurophysiological explanation peculiar subjective experience aberrant generation corollary discharge (CD) by efference copy mechanisms (Feinberg, 2011). More recently, predictive coding theories began add integrated structured framework previous observations (Van de Cruys 2014; Moran 2015). We herein attempt reconcile major currently established psychopathology.