New copper-based complexes with quinoxaline N1,N4-dioxide derivatives, potential antitumoral agents

摘要: Abstract Taking into account our previous studies on cytotoxic metal compounds, new copper complexes with 3-aminoquinoxaline-2-carbonitrile N 1 , 4 -dioxide derivatives as ligands were synthesized and characterized by different spectroscopic methods. The hypoxic selective cytotoxicity towards V79 cells the superoxide dismutase-like activity of determined related to physicochemical properties compounds. In particular, copper(II) complex 3-amino-6-chloro-7-fluoroquinoxaline-2-carbonitrile showed selectivity in hypoxia being most lipophilic compound series. On contrary, was but not that 3-amino-7-chloro-6-methoxy-quinoxaline-2-carbonitrile neither oxia nor assayed conditions. σ m Hammett substituent electronic descriptor effect conditions SOD-like correlated normoxia.