Growth-modulating plasma tripeptide may function by facilitating copper uptake into cells.
作者： Loren Pickart , Jonathan H. Freedman , W. John Loker , Jack Peisach , Christopher M. Perkins
DOI: 10.1038/288715A0
关键词: Copper 、 Tripeptide 、 Biochemistry 、 Albumin 、 Peptide 、 Function (biology) 、 Chemistry 、 Homology (chemistry) 、 Residue (chemistry) 、 Metal
摘要: The plasma tripeptide glycyl-l-histidyl-l-lysine (GHL), when added at nanomolar concentrations to a wide group of cultured systems, produces a disparate set of responses ranging from the stimulation of growth and differentiation to outright toxicity1–3. Such diverse actions imply that this tripeptide mediates some basic biochemical function common to many types of cells and organisms. During the isolation of GHL we found the compound to co-isolate through a number of steps with approximately equimolar copper and about 1/5 molar …
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