Driver Gene and Novel Mutations in Asbestos-Exposed Lung Adenocarcinoma and Malignant Mesothelioma Detected by Exome Sequencing
作者： Satu Mäki-Nevala , Virinder Kaur Sarhadi , Aija Knuuttila , Ilari Scheinin , Pekka Ellonen
DOI: 10.1007/S00408-015-9814-7
关键词: Mesothelioma 、 Exome sequencing 、 Asbestos 、 Gene mutation 、 Adenocarcinoma 、 Pathology 、 Cancer 、 KRAS 、 Medicine 、 Lung cancer
摘要: Background Asbestos is a carcinogen linked to malignant mesothelioma (MM) and lung cancer. Some gene aberrations related asbestos exposure are recognized, but many associated mutations remain obscure. We performed exome sequencing determine the association of previously known (driver mutations) with identify novel in adenocarcinoma (LAC) MM.
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