Malignant Mesothelioma: Mechanism of Carcinogenesis

摘要: Almost 60 years ago, malignant mesothelioma (MM) was acknowledged as a specific cancer related to the inhalation of asbestos fibers (Wagner et al., Br J Ind Med. 17:260–271, 1960). Its strong association with exposure triggered development researches. They consisted epidemiological studies know risk factors that explain MM occurrence in population and experimental understand biological neoplastic disease. Since then, remains rare highly aggressive prompts researches better manage patients offer efficient therapies. To achieve this goal, solid knowledge mechanisms mesothelial carcinogenesis is needed deserves basic progress. So far, our based on pathophysiological toxicological from molecular using tissue tumor samples cell lines humans animals. Most have been cellular and/or animal responses genetically modified mice, demonstrating genotoxic effect relationship induction. The large-scale analyses allowing global integration networks involved transformation should increase understanding carcinogenesis. In human, tumors appeared heterogeneous entities, morphological patterns specificities including gene mutations. recent high-throughput methods allowed classification according their histological type, genomic epigenomic characteristics, deregulated pathways. aim present review propose potential mechanism by integrating data, underlying may be shared other types pose current health issue.