Investigating the Role of Cross-Talk Between Chemical and Stromal Factors in Endothelial Cell Phenotype Determination

摘要: Signal transduction is part of a complex communication system responsible for regulating fundamental cellular activities, including metabolism, protein synthesis, division, migration, and survival. The capacity cells to perceive precisely respond their environment critical development, tissue repair, normal homeostasis. Vast amounts disparate, postgenomic data facilitated by the development high-throughput technologies are now available computational modeling needed synthesize understand these within systems biology context. In this chapter, we discuss approaches model signal present several types Boolean network models cell signaling during tumor angiogenesis. Using models, investigate role cross-talk between chemical stromal factors in endothelial phenotype determination. Understanding principal mechanisms underpinning functions signalling networks will enable identification targets pharmacological interventions treatment cancer other angiogenesis-dependent diseases.