A process for the preparation of lapatinib and its ditosylate salt
作者： Carlos Zetina-Rocha , Mohammed Abdul Raheem , Eduardo Gustavo Cammisa , Gamini Weeratunga
DOI:
关键词: Catalytic hydrogenation 、 Lapatinib 、 Salt (chemistry) 、 Organic chemistry 、 Aldehyde 、 Scientific method 、 Chemistry 、 Reductive amination 、 Catalysis
摘要: There is provided processes for preparing Lapatinib and pharmaceutically acceptable salts thereof by the reductive amination of aldehyde Formula II treatment with 2-methanesulphonylethylamine followed catalytic hydrogenation in presence a suitable catalyst.
lens.org 参考文章(7)
Bhujanga rao Adibhatla Kali Satya, Ramanadham Jyothi Prasad, Nannapaneni Venkaiah Chowdary, A novel process for the preparation of lapatinib and its pharmaceutically acceptable salts ,(2009)
Frank Glaxosmithkline Roschangar, Mark J. Glaxosmithkline Sacchetti, Martin H. Glaxosmithkline Osterhout, Michael S. Glaxosmithkline Mcclure, Quinazoline ditosylate salt compounds ,(2001)
Effect of Preparation Conditions on the Hydrogenation Activity and Metal Dispersion of Pt/C and Pd/C Catalysts Bulletin of The Korean Chemical Society. ,vol. 26, pp. 563- 568 ,(2005) , 10.5012/BKCS.2005.26.4.563
Yuanlian Liu, Yung-Fa Chen, Xiaoheng Zhang, Guodong Chu, Julian Paul Henschke, Process and intermediates for preparing lapatinib ,(2011)
Leonid Metsger, Noa Kipnis, Sofia Gorohovsky-Rosenberg, Dikla Lavy, Slavik Yurkovski, Lapatinib, salts thereof, processes and intermediates for their preparation ,(2009)
André Robichaud, Abdelaziz Nait Ajjou, First example of direct reductive amination of aldehydes with primary and secondary amines catalyzed by water-soluble transition metal catalysts Tetrahedron Letters. ,vol. 47, pp. 3633- 3636 ,(2006) , 10.1016/J.TETLET.2006.03.153
Zhang Zhantao, Zhu Yidong, Leng Chuanxin, Zhang Jin, Wang Jingyi, Zhang Minghui, Fan Chuanwen, Lin Dong, NEW PREPARATION METHOD OF LAPATINIB ,(2011)