Effect of oxiplex* films (PEO/CMC) on adhesion formation and reformation in rabbit models and on peritoneal infection in a rat model.
作者： Kathleen E Rodgers , Herbert E Schwartz , Norma Roda , Melvin Thornton , William Kobak
DOI: 10.1016/S0015-0282(99)00642-1
关键词: Biocompatibility 、 Bacterial Peritonitis 、 Ultimate tensile strength 、 Outcome measures 、 Peritonitis 、 Biomedical engineering 、 Rat model 、 Peritoneal Infection 、 Adhesion 、 Surgery 、 Chemistry
摘要: Abstract Objective: To assess the efficacy of Oxiplex (FzioMed, Inc., San Luis Obispo, CA) barriers. Design: Film polyethylene oxide and carboxymethylcellulose (Oxiplex) were tested for strength tissue adherence. Films selected evaluation in models biocompatability Three films studies, one was evaluated effects on bacterial peritonitis. Handling characteristics film via laparoscopy. Setting: University laboratory. Patient(s): Rabbits, rats, pigs. Intervention(s): Placement prototypes at site injury. Main Outcome Measure(s): Mechanical properties, biocompatibility, adherence, adhesion development, infection potentiation, device handling. Result(s): tests indicated that tensile elongation inversely correlated. All had excellent adherence properties. Selected films, based residence time prevented formation all animals highly efficacious preventing reformation. The optimal prototype reformation 91% animals. This film, dyed to allow visualization, did not affect In a laparoscopic model, delivered FilmSert forceps, 5.0-mm trocar, rapidly unfurled could be easily applied with strong Conclusion(s): These data show development an prevention material is adherent, can placed laparoscopy, does host resistance.
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Eishun Tsuchida, Koji Abe, Interactions Between Macromolecules in Solution and Intermacromolecular Complexes ,(1982)
Stricker B, Blanco J, Fox He, The gynecologic contribution to intestinal obstruction in females Journal of The American College of Surgeons. ,vol. 178, pp. 617- 620 ,(1994)
Gere S. diZerega, Contemporary adhesion prevention Fertility and Sterility. ,vol. 61, pp. 219- 235 ,(1994) , 10.1016/S0015-0282(16)56507-8
A. J. Domb, Polymeric site-specific pharmacotherapy J. Wiley. ,(1994)
Donald L. Elbert, Jeffrey A. Hubbell, Reduction of fibrous adhesion formation by a copolymer possessing an affinity for anionic surfaces Journal of Biomedical Materials Research. ,vol. 42, pp. 55- 65 ,(1998) , 10.1002/(SICI)1097-4636(199810)42:1<55::AID-JBM8>3.0.CO;2-N
A. A. W. PETERS, G. C. M. TRIMBOS-KEMPER, C. ADMIRAAL, J. B. TRIMBOS, J. HERMANS, A randomized clinical trial on the benefit of adhesiolysis in patients with intraperitoneal adhesions and chronic pelvic pain. British Journal of Obstetrics and Gynaecology. ,vol. 99, pp. 59- 62 ,(1992) , 10.1111/J.1471-0528.1992.TB14394.X
Kathleen E. Rodgers, Wefki Girgis, Joseph D. Campeau, Gere S. diZerega, Reduction of Adhesion Formation by Intraperitoneal Administration of Anti-inflammatory Peptide 2 Journal of Investigative Surgery. ,vol. 10, pp. 31- 36 ,(1997) , 10.3109/08941939709032122
K. E. Rodgers, W. Girgis, K. St Amand, J. Campeau, G. S. diZerega, Reduction of adhesion formation in rabbits by intraperitoneal administration of lazaroid formulations. Human Reproduction. ,vol. 13, pp. 2443- 2451 ,(1998) , 10.1093/HUMREP/13.9.2443
Stephen D. Cook, Ann B. Prewett, Jeanette E. Dalton, ME, Thomas S. Whitecloud, Reduction in perineural scar formation after laminectomy with Polyactive membrane sheets. Spine. ,vol. 19, pp. 1815- 1825 ,(1994) , 10.1097/00007632-199408150-00005
R. S. Manly, Adhesion in biological systems. Science. ,vol. 158, pp. 812- 812 ,(1967) , 10.1126/SCIENCE.158.3802.812