Polyvinyl alcohol hydrogel decreases formation of adhesions in a rat model of peritonitis.
作者： Eva B. Deerenberg , Irene M. Mulder , Max Ditzel , Juliette C. Slieker , Willem A. Bemelman
DOI: 10.1089/SUR.2011.108
关键词: Abscess 、 Medicine 、 Peritonitis 、 Histopathology 、 Adhesion (medicine) 、 Polyvinyl alcohol 、 Polyvinyl alcohol hydrogel 、 Postoperative complication 、 Surgery 、 Rat model
摘要: Abstract Background: Adhesion formation after surgery for peritonitis-related conditions, with such associated complications as intestinal obstruction, pain, and infertility, remains an important problem. Applying a liquid barrier intra-peritoneally might reduce initial adhesion formation. Methods: A combination of the cecal ligation puncture model peritonitis side-wall defect (SWD) was performed. Forty rats were assigned randomly to receive no or 1 mL 2 mL cross-linked polyvinyl alcohol carboxymethylcellulose (PVA/CMC) hydrogel A-Part® Gel (B. Braun Aesculap AG, Tuttlingen, Germany). After 14 days, animals sacrificed, abscess scored. Results: Thirty survived, distributed equally among groups. There significantly fewer adhesions SWD in PVA/CMC groups (median 0) than control group 26%–50%) (p<0.05). The median tenacity significa...
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