Inhibition of hormone-sensitive lipase by intermediary lipid metabolites
作者： Catherine A. Jepson , Stephen J. Yeaman
DOI: 10.1016/0014-5793(92)81328-J
关键词: Biochemistry 、 Coenzyme A 、 Lipid metabolism 、 Hormone-sensitive lipase 、 Enzyme 、 Cholesterol 、 Endocrinology 、 Internal medicine 、 Biology 、 Monoacylglycerol lipase 、 Oleic acid 、 Lipase 、 Biophysics 、 Genetics 、 Cell biology 、 Molecular biology 、 Structural biology
摘要: Hormone-sensitive lipase (HSL) is inhibited in a non-competitive manner by oleoyl CoA, oleic acid and 2-monopalmitoylglycerol, 50% inhibition being observed at concentrations of approx. 0.1 μM, 0.5 μM 500 respectively. HSL key enzyme lipid metabolism, mobilising triacylglycerol cholesterol ester stores several tissues. Feedback CoA may therefore prevent accumulation free fatty acids the cell, whereas 2-monoacylglycerol act as feedback inhibitor if capacity monoacylglycerol exceeded.
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