Chemoselective synthesis of quinoxalines and benzimidazoles by silica gel catalysis
作者： Chunmei Li , Furen Zhang , Zhen Yang , Chenze Qi
DOI: 10.1016/J.TETLET.2014.08.022
关键词: Reaction mechanism 、 Benzimidazole 、 Catalysis 、 Chemistry 、 Silica gel 、 Substrate (chemistry) 、 Quinoxaline 、 Organic chemistry
摘要: Treatment of nitroolefins and o-phenylenediamine with silica gel catalyst produced quinoxalines mainly in THF, but gave benzimidazoles efficiently water. Such a solvent-dependent chemoselective reaction has prominent features affording two cyclized products selectively the same substrate, short time, operational simplicity, as well available starting materials nontoxic catalysts. In addition, scope limitations were explored plausible mechanism is proposed.
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