Water mediated chemoselective synthesis of 1,2-disubstituted benzimidazoles using o-phenylenediamine and the extended synthesis of quinoxalines
作者： Jie-Ping Wan , Shi-Feng Gan , Jian-Mei Wu , Yuanjiang Pan
DOI: 10.1039/B914286J
关键词: o-Phenylenediamine 、 Aldehyde 、 Chloride 、 Catalysis 、 Organic chemistry 、 Selectivity 、 Chemistry
摘要: By applying water as the reaction medium, one-pot synthesis of 1,2-disubstituted benzimidazoles has been achieved in excellent efficiency and selectivity at room temperature viatrimethylsilyl chloride promoted o-phenylenediamine with aldehyde. This green catalyst system also successfully extended to quinoxalines via α-bromoketone. Water displayed a specific functionality mediating selectivity, remarkable advantages over organic solvents terms yields well work up procedure reactions.
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