Limited maximal vasodilator capacity of forearm resistance vessels in patients with hypertrophic cardiomyopathy
作者： Tsutomu Imaizumi , Akira Takeshita , Kunihiko Yamamoto , Motoomi Nakamura , Katsuo Sueishi
DOI: 10.1007/BF02059911
关键词: Forearm 、 Reactive hyperemia 、 Cardiology 、 Vascular disease 、 Vasodilation 、 Vascular resistance 、 Angiotensin II 、 Hypertrophic cardiomyopathy 、 Medicine 、 Plethysmograph 、 Internal medicine 、 Cardiology and Cardiovascular Medicine
摘要: It is not known whether hypertrophic cardiomyopathy (HCM) accompanied by an abnormality in vascular smooth muscles. In this study, we examined the maximal vasodilator capacity of forearm resistance vessels measuring minimal (min. FVR) during peak reactive hyperemia after 10 min arterial occlusion patients with HCM (n=15, 41±4 years old) and age-matched control subjects (n=12, 42±3 old). Forearm blood flow (FBF) was measured a mercury-in-silastic strain gauge plethysmograph FVR calculated dividing mean pressure FBF. Resting FBF lower (P<0.05) resting higher (P<0.01) than subjects. Min. significantly greater (2.7±0.2 vs 1.5±0.2 units,P<0.005). We also vasoconstrictive responses to intra-arterially infused angiotensin II (20 40 ng/min); were (P<0.05). These results indicate that circulation altered HCM. The result limited as compared suggests there may be abnormalities HCM, which might involve increased wall thickness or intrinsic muscle.
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