Thymidylate Synthase Gene Polymorphism and Survival of Colorectal Cancer Patients Receiving Adjuvant 5-Fluorouracil

摘要: Limited studies indicate a possible association of 5′-UTR thymidylate synthase enhancer region polymorphism and treatment outcome in patients medicated with 5-fluorouracil (5-FU). The study was designed to verify the relationship colorectal cancer (CRC), Polish population that received 5-FU-based adjuvant chemotherapy. analyzed 145 Astler-Coller B2 C CRC patients. Genotyping for variable number tandem repeats G single-nucleotide (TS) gene carried out. TS genotypes were classified into high expression (high TS) low types (low TS). High found 22.8% right-side tumors more frequently associated than left-side (p=0.024). only 9.3% rectal tumors, but 29.7% colon cancers (p=0.0042). Disease-free survival after 20 months (DFS 20) longer subjects (p=0.043). Patients who underwent chemotherapy had DFS subgroup (p=0.051). be an independent good prognostic factor whole group as well treated (p=0.024 p=0.034, respectively). did not show any differences whether they or not. Proximal are characterized by higher distal at significantly greater risk early recurrence during first surgery.