Close Proximity to Igh Is a Contributing Factor to AID-Mediated Translocations
作者： Pedro P. Rocha , Mariann Micsinai , JungHyun Rachel Kim , Susannah L. Hewitt , Patricia P. Souza
DOI: 10.1016/J.MOLCEL.2012.06.036
关键词: Gene 、 Locus (genetics) 、 Genetics 、 Cytidine deaminase 、 Chromosomal translocation 、 Immunoglobulin class switching 、 Nuclear organization 、 Genome instability 、 Biology
摘要: Summary Class switch recombination (CSR) has the potential to generate genomic instability in B cells as activation-induced cytidine deaminase (AID), which mediates this process, is known target many sites outside Igh . Nonetheless we do not fully understand what factors influence AID targeting genome-wide. Given that errors CSR can lead dangerous, oncogenic chromosomal translocations it important identify elements determine genes are at risk of being "hit" and could be involved aberrant rearrangements. Here have investigated nuclear organization determining "off-target" activity choice fusion partners. Our studies indicate vast majority AID-mediated translocation partners found domains contact locus during class switching. Further, these interaction used other hit by AID.
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