Minding the gap: The underground functions of BRCA1 and BRCA2 at stalled replication forks
作者： G NAGARAJU , R SCULLY
DOI: 10.1016/J.DNAREP.2007.02.020
关键词: RAD51 、 S phase 、 Biology 、 Genetics 、 DNA repair 、 Homologous recombination 、 DNA replication 、 Control of chromosome duplication 、 Eukaryotic DNA replication 、 Genome instability
摘要: The hereditary breast and ovarian cancer predisposition genes, BRCA1 BRCA2, participate in the repair of DNA double strand breaks by homologous recombination. Circumstantial evidence implicates these genes recombinational responses to polymerase stalling during S phase cell cycle. These play a key role preventing genomic instability cancer. Here, we review current literature implicating BRCA pathway HR at stalled replication forks explore hypothesis that BRCA2 resolution single stranded lesions termed "daughter gaps", generated across damaged template.
elsevier.com
sci-hub.se 参考文章(160)
Luke Hughes-Davies, David Huntsman, Margarida Ruas, Francois Fuks, Jacqueline Bye, Suet-Feung Chin, Jonathon Milner, Lindsay A Brown, Forrest Hsu, Blake Gilks, Torsten Nielsen, Michael Schulzer, Stephen Chia, Joseph Ragaz, Anthony Cahn, Lori Linger, Hilal Ozdag, Elena Cattaneo, ES Jordanova, Edward Schuuring, S Yu David, Ashok Venkitaraman, Bruce Ponder, Aidan Doherty, Samuel Aparicio, David Bentley, Charles Theillet, Chris P Ponting, Carlos Caldas, Tony Kouzarides, None, EMSY Links the BRCA2 Pathway to Sporadic Breast and Ovarian Cancer Cell. ,vol. 115, pp. 523- 535 ,(2003) , 10.1016/S0092-8674(03)00930-9
D B Sweetser, H Hough, J F Whelden, M Arbuckle, J A Nickoloff, Fine-resolution mapping of spontaneous and double-strand break-induced gene conversion tracts in Saccharomyces cerevisiae reveals reversible mitotic conversion polarity. Molecular and Cellular Biology. ,vol. 14, pp. 3863- 3875 ,(1994) , 10.1128/MCB.14.6.3863
Jeremy M. Stark, Maria Jasin, Extensive loss of heterozygosity is suppressed during homologous repair of chromosomal breaks. Molecular and Cellular Biology. ,vol. 23, pp. 733- 743 ,(2003) , 10.1128/MCB.23.2.733-743.2003
A Suzuki, J L de la Pompa, R Hakem, A Elia, R Yoshida, R Mo, H Nishina, T Chuang, A Wakeham, A Itie, W Koo, P Billia, A Ho, M Fukumoto, C C Hui, T W Mak, Brca2 is required for embryonic cellular proliferation in the mouse. Genes & Development. ,vol. 11, pp. 1242- 1252 ,(1997) , 10.1101/GAD.11.10.1242
Ganesh Nagaraju, Shobu Odate, Anyong Xie, Ralph Scully, Differential Regulation of Short- and Long-Tract Gene Conversion between Sister Chromatids by Rad51C Molecular and Cellular Biology. ,vol. 26, pp. 8075- 8086 ,(2006) , 10.1128/MCB.01235-06
Stephen J. Elledge, Parvin Yazdi, Jun Qin, David Cortez, Norma Neff, Yi Wang, BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures Genes & Development. ,vol. 14, pp. 927- 939 ,(2000) , 10.1101/GAD.14.8.927
H H Nelson, D B Sweetser, J A Nickoloff, Effects of terminal nonhomology and homeology on double-strand-break-induced gene conversion tract directionality Molecular and Cellular Biology. ,vol. 16, pp. 2951- 2957 ,(1996) , 10.1128/MCB.16.6.2951
Sarah Reid, Detlev Schindler, Helmut Hanenberg, Karen Barker, Sandra Hanks, Reinhard Kalb, Kornelia Neveling, Patrick Kelly, Sheila Seal, Marcel Freund, Melanie Wurm, Sat Dev Batish, Francis P Lach, Sevgi Yetgin, Heidemarie Neitzel, Hany Ariffin, Marc Tischkowitz, Christopher G Mathew, Arleen D Auerbach, Nazneen Rahman, Biallelic mutations in PALB2 cause Fanconi anemia subtype FA-N and predispose to childhood cancer Nature Genetics. ,vol. 39, pp. 162- 164 ,(2007) , 10.1038/NG1947
Mitch McVey, Melissa Adams, Eric Staeva-Vieira, Jeff J. Sekelsky, Evidence for multiple cycles of strand invasion during repair of double-strand gaps in Drosophila. Genetics. ,vol. 167, pp. 699- 705 ,(2004) , 10.1534/GENETICS.103.025411
James E. Haber, Giovanni Bosco, Chromosome Break-Induced DNA Replication Leads to Nonreciprocal Translocations and Telomere Capture Genetics. ,vol. 150, pp. 1037- 1047 ,(1998) , 10.1093/GENETICS/150.3.1037