Kaempferia parviflora and Its Methoxyflavones: Chemistry and Biological Activities.
作者： Dalin Chen , Hongliang Li , Wen Li , Shuo Feng , Dingsen Deng
DOI: 10.1155/2018/4057456
关键词: Pharmacology 、 Neuroprotection 、 Transdermal 、 Kaempferia parviflora 、 Chemistry 、 Bioavailability
摘要: Kaempferia parviflora (KP), a health-promoting herb, has been traditionally used for treating variety of diseases. Pharmacological studies have claimed the various benefits from KP and its main effective methoxyflavones, including cellular metabolism-regulating activity, anticancer vascular relaxation cardioprotective sexual enhancing neuroprotective antiallergic, anti-inflammatory, antioxidative antiosteoarthritis antimicroorganism transdermal permeable activity. These might be associated with increased mitochondrial functions activated cGMP-NO signaling pathway. However, underlying molecular mechanisms methoxyflavones are still under investigation. The clinical applications may limited due to their low bioavailability. But promising strategies on way. This review will comprehensively discuss biological activities methoxyflavones.
hindawi.com参考文章(78)
K Sookkongwaree, S Roengsumran, A Petsom, M Geitmann, U H Danielson, Inhibition of viral proteases by Zingiberaceae extracts and flavones isolated from Kaempferia parviflora. Pharmazie. ,vol. 61, pp. 717- 721 ,(2006)
Ratana Banjerdpongchai, Viboon Rattanapanone, Bungorn Sripanidkulchai, Yupa Chanwikruy, Induction of apoptosis in the human Leukemic U937 cell line by Kaempferia parviflora Wall.ex.Baker extract and effects of paclitaxel and camptothecin. Asian Pacific Journal of Cancer Prevention. ,vol. 10, pp. 1137- 1140 ,(2009)
Mami MATSUSHITA, Takeshi YONESHIRO, Sayuri AITA, Tomoyasu KAMIYA, Nobutaka KUSABA, Kazuya YAMAGUCHI, Kinya TAKAGAKI, Toshimitsu KAMEYA, Hiroki SUGIE, Masayuki SAITO, Kaempferia parviflora extract increases whole-body energy expenditure in humans: roles of brown adipose tissue. Journal of Nutritional Science and Vitaminology. ,vol. 61, pp. 79- 83 ,(2015) , 10.3177/JNSV.61.79
Uraiwan Chatchawan, Effect of Kaempferia parviflora Extract on Physical Fitness of Soccer Players: A Randomized Double-Blind Placebo-Controlled Trial Medical Science Monitor Basic Research. ,vol. 21, pp. 100- 108 ,(2015) , 10.12659/MSMBR.894301
Jianqiong Yang, Haiqing Liu, Linfu Li, Hai Liu, Weimei Shi, Longhuo Wu, The Chondroprotective Role of TMF in PGE2-Induced Apoptosis Associating with Endoplasmic Reticulum Stress Evidence-based Complementary and Alternative Medicine. ,vol. 2015, pp. 297423- 297423 ,(2015) , 10.1155/2015/297423
Ji-Eun Park, Hee-Bong Pyun, Seon Wook Woo, Jae-Hong Jeong, Jae-Kwan Hwang, The protective effect ofKaempferia parvifloraextract on UVB-induced skin photoaging in hairless mice Photodermatology, Photoimmunology & Photomedicine. ,vol. 30, pp. 237- 245 ,(2014) , 10.1111/PHPP.12097
Hiroko Kobayashi, Emi Horiguchi-Babamoto, Mio Suzuki, Hiroko Makihara, Hiroshi Tomozawa, Masahito Tsubata, Tsutomu Shimada, Kiyoshi Sugiyama, Masaki Aburada, Effects of ethyl acetate extract of Kaempferia parviflora on brown adipose tissue Journal of Natural Medicines. ,vol. 70, pp. 54- 61 ,(2016) , 10.1007/S11418-015-0936-2
Aimmanas Attawish, Pranee Chavalittumrong, Songpol Chivapat, Anudep Rungsipipat, Chronic toxicity study of Kaempferia parviflora Wall ex. extract Thai Journal of Veterinary Medicine. ,vol. 40, pp. 377- 383 ,(2010)
Prapapan Temkitthawon, Thomas R. Hinds, Joseph A. Beavo, Jarupa Viyoch, Khanit Suwanborirux, Wittaya Pongamornkul, Pattara Sawasdee, Kornkanok Ingkaninan, Kaempferia parviflora, a plant used in traditional medicine to enhance sexual performance contains large amounts of low affinity PDE5 inhibitors Journal of Ethnopharmacology. ,vol. 137, pp. 1437- 1441 ,(2011) , 10.1016/J.JEP.2011.08.025
Susumu Yoshino, Minji Kim, Riyo Awa, Hiroshige Kuwahara, Yuriko Kano, Teruo Kawada, Kaempferia parviflora extract increases energy consumption through activation of BAT in mice. Food Science and Nutrition. ,vol. 2, pp. 634- 637 ,(2014) , 10.1002/FSN3.144