The use of cephalosporins for gonorrhea: the impending problem of resistance

摘要: Gonorrhea remains an important clinical and public health problem throughout the world. Gonococcal infections have historically been diagnosed by Gram stain culture but are increasingly through nucleic acid tests, thereby eliminating opportunity for antimicrobial susceptibility testing. typically treated with single-dose therapy agent found to cure > 95% of cases. Unfortunately, gonococcus has repeatedly developed resistance antimicrobials including sulfonamides, penicillin, tetracyclines fluoroquinolones. This now left third-generation cephalosporins as lone class recommended first-line gonorrhea in some regions. However, oral emerged spread Asia, Australia elsewhere. The mechanism this seems be associated a mosaic penicillin binding protein (penA) addition other chromosomal mutations previously confer res...