A dose‐response study of HOE 498, a new non‐sulphydryl converting enzyme inhibitor, on blood pressure, pulse rate and the renin‐ angiotensin‐aldosterone system in normal man.

摘要: The effect of different oral doses HOE 498, a new non-sulphydryl containing converting enzyme inhibitor, was investigated in double-blind, placebo-controlled study normotensive volunteers. Dose-related reductions serum activity, plasma angiotensin II and aldosterone were seen, greater at 4 h than 12 after drug ingestion. Converse dose-related increases blood I active renin concentration occurred. Falls as great with 20 mg 50 although the more prolonged mg. concentrations activity correlated 498 - diacid plasma. falls both supine erect pressure maximal 2-3.5 dosing. Pulse rate increased marginally but insignificantly supine; slightly significantly upright position, concomitantly reduction all drug. We conclude that effects single on renin-angiotensin system are within h, still apparent 24 h. Thus it is likely once daily administration will be adequate for treatment high patients.