Detection of subclinical keratoconus through non-contact tonometry and the use of discriminant biomechanical functions.

摘要: The purpose of the present study was to develop a discriminant function departing from biomechanical parameters provided by non-contact tonometer (Corvis-ST, Oculus Optikgerate, Wetzlar, Germany) distinguish subclinical keratoconus normal eyes. 212 eyes (120 patients) were divided in two groups: 184 healthy 92 patients aged 32.99 ± 7.85 (21-73 years) and 28 37.79 14.21 (17-75 with keratoconus. main outcome measures age, sex, intraocular pressure (IOP), corneal central thickness (CCT) other specific tonometer. Correlations between all rest variables evaluated. corrected IOP CCT (since these variable are not directly related structure behavior) warrant an accurate comparison both types Two functions created set variables. best depended on three parameters: maximum Deformation Amplitude (corrected CCT), First Applanation time CCT) CCT. Statistically significant differences found groups for this (p=2·10(-10); Mann-Withney test). area under Receiving Operating Characteristic 0.893 0.028 (95% confidence interval 0.838-0.949). Sensitivity specificity 85.7% 82.07% respectively. These results show that use tonometry, previous normalization, combined theory is useful tool detection