Antinociceptive effect of ethanolic extract of Hybanthus enneaspermus leaf in rats.
作者： A Afolabi , E Oluwakanmi , H Salahdeen , A Oyekunle , I Alagbonsi
关键词: Nociception 、 Hybanthus enneaspermus 、 Traditional medicine 、 Licking 、 Tail flick latency 、 Acetaminophen 、 Distilled water 、 Medicine 、 Early phase 、 Oral administration
摘要: Aims: To test the hypothesis that Hybanthus enneaspermus leaf has an antinociceptive effect. Methodology: Seventy-two male rats were randomly divided in a blinded fashion into 4 groups each for tail immersion (n=12 per group) and formalin (n=6 group). Group 1 (control) received 0.6 ml of distilled water. 2 100 mg/kg acetaminophen (paracetamol). 3 500 1000 ethanolic extract (EEHE) respectively. Results: In test, oral administration EEHE caused inhibitions 62.48% 72% early phase 70.54% 78.63% Research Article British Journal Medicine & Medical Research, 4(1): 322-330, 2014 323 late The dose significantly reduced paw licking time when compared to standard drug (acetaminophen) test. doses increased flick latency manner comparable acetaminophen. Conclusion: This study showed anti-nociceptive
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