Pain sensitivity and opioid activity in genetically and experimentally hypertensive rats
作者： N. Zamir , R. Simantov , M. Segal
DOI: 10.1016/0006-8993(80)90800-8
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摘要: Abstract Pain sensitivity was studied in renal and DOCA-salt hypertensive rats, two strains of rats derived from the same parental strain for their (H) or immunity (N) to hypertension induced by treatment. Experimentally H N were less sensitive painful stimuli than appropriate controls, as assessed hot-plate paw tests. Naloxone reversed this hypoalgesia both experimentally genetically while it did not affect blood pressure any rat-type tested. Opioid activity measured with radioreceptor assay several brain regions pituary gland rats. had a 45% higher level opioid spinal cord compared control. Rats exhibited levels cord, hypothalamus pituitary. It is suggested that control systems pain are closely associated rat.
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