The potential usefulness of human leukocyte antigen typing for celiac disease screening: A systematic review and meta-analysis.

摘要: Background and aim: The presence of specific human leukocyte antigen-DQ2 DQ8 seems to be necessary for celiac disease development, but the real contribution its typing for screening is still uncertain. We aim conduct a systematic review meta-analysis diagnostic performance antigen typing tests for celiac screening. Methods: Systematic review published studies assessing accuracy human leukocyte DQ2 the detection were selected. MEDLINE EMBASE were searched from 1st January 2004 until 31st December 2013. Two independent researchers carried out selection classification of studies, data extraction analysis. Meta-analysis combining sensitivities, specificities likelihood ratios HLA-DQ2 and DQ8 diagnosis out. Results: 6 including 1303 individuals finally evaluated. Pooled sensitivity was 98% (95% confidence interval: 97-99). Overall specificity 45% interval: 41-48). Regarding specificity, heterogeneous a subgroup analysis done according type population included. negative ratio 0.05 (0.03-0.09). Conclusions: Due great low negative likelihood ratio, antigen-DQ2/DQ8 would be an appropriate test ruling in general population suffering related symptoms, even more at risk population.