Amerindian mtDNA haplogroups and celiac disease risk HLA haplotypes in mixed-blood Latin American patients.
作者： Alejandra Parada , Magdalena Araya , Francisco Pérez-Bravo , Marco Méndez , Adriana Mimbacas
DOI: 10.1097/MPG.0B013E31821DE3FC
关键词:
摘要: BACKGROUND AND OBJECTIVE Risk haplotypes have been described in celiac disease (CD), but the influence of native genes on CD Hispanic Americans is unknown. The aim study was to measure frequency Amerindian mitochondrial DNA (mtDNA) haplogroups (inherited by maternal line) mixed-blood patients with from Chile, Argentina, and Uruguay, assess relation between these human leukocyte antigen (HLA) alleles clinical presentations. PATIENTS METHODS Clinical history, histological data, genetic studies were conducted following 2 protocols: a case-control 72 Chilean controls, an assessment 43 (additional) samples 96 57 compared mtDNA corresponding country. HLA typing performed commercial kit, determined means polymerase chain reaction restriction fragment length polymorphisms analysis. RESULTS A total 73.6% cases had typical most frequent HLA-DQB*201 202. No-DQ2/DQ8 found 7% cases. frequencies for 71% 64% controls (P χ2 = 0.016); comparative analysis, distribution not different figures reported respective general country population. No or CONCLUSIONS A/B/C/D frequently no relations appeared haplogroups, haplotypes,
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