Identification of DHODH as a therapeutic target in small cell lung cancer.

作者: Leanne Li , Sheng Rong Ng , Caterina I. Colón , Benjamin J. Drapkin , Peggy P. Hsu

DOI: 10.1126/SCITRANSLMED.AAW7852

关键词: Lung cancerDihydroorotate dehydrogenaseCancer researchGeneGenetically Engineered MouseCell cultureBiologyGenetic screenAdenocarcinomaDruggability

摘要: … finding by pharmacological inhibition of DHODH. In addition to … DHODH, brequinar (15) and leflunomide (16), we observed that SCLC cell lines displayed higher sensitivity to DHODH …

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