17β-Oestradiol enhances the acute hypotensive effect of captopril in female ovariectomized spontaneously hypertensive rats

摘要: The objective of this study was to investigate whether the acute haemodynamic effects angiotensin-converting enzyme inhibition with captopril could be enhanced by oestrogen administration, and then evaluate mechanisms involved in enhancement. All experiments were performed 18-week-old female spontaneously hypertensive rats arranged three experimental groups: intact; ovariectomized (OVX); plus treatment 17beta-oestradiol (OVX + E2). These groups used administration alone, or following bradykinin B2 receptor blockade nitric oxide synthase inhibition, on a number parameters (mean arterial pressure, cardiac index, vascular resistance heart rate). drop mean pressure index response more pronounced intact treated than animals. Blockade receptors synthesis attenuated synergy between captopril. It is concluded that ovariectomy blunted blood observed Treatment prevented rats. Kinins may potentiation