Regulation of death receptors--relevance in cancer therapies.

摘要: Apoptosis is an essential non-inflammatory mechanism for cell removal, which occurs during both physiological and pathological conditions. characteristically executed by cysteine proteases, termed caspases. The most specific way to activate the caspases machinery through death receptors (DRs), such as tumor necrosis factor (TNFR), Fas receptor (FasR), TRAIL (TRAIL-R). apoptotic signaling tightly regulated balance of pro-apoptotic anti-apoptotic proteins imbalance between proliferation may cause numerous diseases, including cancers. intensive research past decade has delineated basic mechanisms apoptosis outlined many important molecular underlying regulation apoptosis. There also a better understanding how can be disturbed in human cancer cells. interplay DRs anticancer drugs offered new concepts development highly therapeutical agents. Here we review current different that regulate DR-mediated defects discovered In light this knowledge, promising target-based agents future therapies have been developed.