Polyethylene sebacate-doxorubicin nanoparticles for hepatic targeting.
作者： Swati A. Guhagarkar , Rajiv V. Gaikwad , Abdul Samad , Vinod C. Malshe , Padma V. Devarajan
DOI: 10.1016/J.IJPHARM.2010.09.012
关键词: Asialoglycoprotein receptor 、 Biodistribution 、 Chelation 、 Nanoparticle 、 Doxorubicin 、 Organic chemistry 、 Aqueous two-phase system 、 Nuclear chemistry 、 Microparticle 、 Chemistry 、 Pullulan
摘要: The present study discusses polyethylene sebacate (PES)-doxorubicin (DOX) nanoparticles (PES-DOX NP) using pullulan as asialoglycoprotein receptor (ASGPR) ligand for hepatic targeting. Pullulan, a hydrophilic polymer served and stealth agent. PES-DOX NP were prepared by modified nanoprecipitation PES Gantrez AN 119 (Gantrez), complexing agent in the organic phase, while DOX was dissolved aqueous phase. Pullulan adsorbed on formed (PES-DOX-PUL). Intimate association of Gantrez, ionic complexation with (confirmed FTIR), coupled rapidity resulted high entrapment efficiency drug loading. Nanoparticles successfully freeze dried. Drug release from followed zero order kinetics. PES-DOX-PUL exhibited low hemolytic potential good serum stability. Comparative biodistribution rats (99m)Tc labeled formulations revealed higher blood concentration lower liver PES-DOX-PUL, confirming long circulating nature thereby possibility improved targeting to hepatocytes. heart suggestive cardiotoxicity. Our presents radically different yet simple approach design loading therapy cancer.
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