Assessing individual interethnic admixture and population substructure using a 48-insertion-deletion (INSEL) ancestry-informative marker (AIM) panel.

摘要: Estimating the proportions of different ancestries in admixed populations is very important population genetics studies, and it particularly for detecting substructure effects case-control association studies. In this work, a set 48 ancestry-informative insertion-deletion polymorphisms (INDELs) were selected with goal efficiently measuring three (sub-Saharan African, European, Native American) mixed populations. All markers can be easily analyzed via multiplex PCR detected standard capillary electrophoresis. A total 593 unrelated individuals representative American parental typed, as 380 from Brazilian known admixture patterns. As expected, interethnic estimates show that southern Brazil present an almost exclusively European ancestry; Afro-descendant communities Amazon region, apart major African contribution, some degree Europeans Americans; sample Belem, northeastern Amazon, shows significant contribution ethnic groups, although greater proportion. summary, panel INDELs was optimized proven to valuable tool estimating individual global ancestry The ability accurately infer admixtures highlights usefulness marker assessing those conducted other Latin sharing trihybrid