The effects of interferon-gamma on the central nervous system.

摘要: Interferon-gamma (IFN-γ) is a pleotropic cytokine released by T-lymphocytes and natural killer cells. Normally, these cells do not traverse the blood-brain barrier at appreciable levels and, as such, IFN-γ generally undetectable within central nervous system (CNS). Nevertheless, in response to CNS infections, well during certain disorders which affected, T-cell traffic across increases considerably, thereby exposing neuronal glial potent effects of IFN-γ. A large portion this article devoted substantial circumstantial experimental evidence that suggests plays an important role pathogenesis demyelinating disorder multiple sclerosis (MS) its animal model allergic encephalomyelitis (EAE). Moreover, biochemical physiological are discussed context potential consequences such activities on developing mature systems.