作者: Truman M. Sasaki , R. Stuart Gray , Robert E. Ratner , Charles Currier , Alex Aquino
DOI: 10.1097/00007890-199806150-00021
关键词: Medicine 、 Internal medicine 、 Diabetes mellitus 、 Transplantation 、 Insulin 、 Gastroenterology 、 C-peptide 、 Pancreatic disease 、 Pancreas 、 Type 1 diabetes 、 Endocrinology 、 Beta cell
摘要: Background. Pancreas transplants are rarely done in type 2 (noninsulin dependent) diabetic patients. Most researchers believe that patients, peripheral insulin resistance plays a central role and also is associated with relative deficiency or an secretory defect. This suggests patients receiving transplants, the new beta cells will be overstimulated, leading to cell exhaustion graft failure. Methods. Early our experience, simultaneous pancreas-kidney transplant candidates were selected using only clinical criteria for 1 diabetes, i.e., early onset of diabetes rapid use. Pretransplant sera available C-peptide analysis 70 94 those Forty-four percent (31/70) African American (AA). Results. Thirteen (12 AA) nonfasting level >1.37 ng/ml identified. In these high levels, pancreas kidney survival rates 100%. The results did not differ statistically from low group (≤1.37 ng/ ml). There no differences between patient when separated into AA non-AA groups. follow-up was 1-89 months, mean 45.5 months. Conclusions. Long-term function attainable does occur preoperative (>1.37 ml) levels. have equivalent long-term patient, kidney, rates.