The Expression of Cytochrome P-450, Epoxide Hydrolase, and Glutathione S- Transferase in Hepatocellular Carcinoma
作者： Graeme I. Murray , Pamela J. Paterson , Richard J. Weaver , Stanley W. B. Ewen , William T. Melvin
DOI: 10.1002/1097-0142(19930101)71:1<36::AID-CNCR2820710107>3.0.CO;2-J
关键词: Epoxide Hydrolases 、 Cytochrome P450 、 Molecular biology 、 Epoxide hydrolase 2 、 Epoxide hydrolase 、 Glutathione S-transferase 、 Microsomal epoxide hydrolase 、 Hepatocellular carcinoma 、 Cytochrome P-450 CYP3A 、 Biology
摘要: Background Cytochrome P-450, epoxide hydrolase, and glutathione S-transferase (GST) all play a key role in the metabolism of chemical carcinogens, mutagens, various anti-cancer drugs. All these functionally associated enzymes might be involved both development hepatocellular carcinoma determining drug sensitivity such tumors. Methods The expression two forms cytochrome P-450 (P-450 IA IIIA), microsomal three classes cytosolic GST (alpha, mu, pi) have been studied immunohistochemically human carcinoma. Results carcinomas were characterized by consistently high hydrolase variable cytochromes GST. IIIA stained 64.5% 41.9% 31 studied, respectively. Epoxide was present tumors, types alpha, pi, mu identified 48.4%, 38.7%, 74.2% carcinomas, Conclusions This study showed that xenobiotic-metabolizing is complex presence different xenobiotic may contribute to intrinsic resistance
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