Harnessing the Potential of Graft-vs-Tumor

摘要: The curative potential of allogeneic hematopoietic stem cell transplantation in treating cancer is derived large part from the donor immune system reacting against host or tumor antigens to generate a graft-vs-tumor (GVT) effect. Whereas early animal models suggested this response, evidence for its role human was not realized until late 1970s and 1980s, when association between graft-vs-host disease response became clear. In chapter, data that established GVT effect as major therapeutic component are reviewed, ongoing efforts understand build on modality other types described. current thinking biology effectors modulators discussed. progress has been made clinical application immunotherapy autologous setting solid therapy reviewed. Finally, continued advances efficacy safety explored, reflected recent apply growing understanding alloreactivity toward fulfillment targeted antitumor therapies.