Three-dimensional imaging of the human retina by high-speed optical coherence tomography

作者: Christoph K. Hitzenberger , Peter Trost , Pak-Wai Lo , Qienyuan Zhou

DOI: 10.1364/OE.11.002753

关键词: Optic nerveOptical coherence tomographyAcousto-optic modulatorMaterials sciencePixelRetinaImage qualityOpticsTransverse planePreclinical imaging

摘要: Conventional optical coherence tomography is based on A-scans, i.e., the fast scan direction z-direction. While this technique has been successfully demonstrated for two-dimensional cross sectional imaging of various tissues, it rather slow if three-dimensional information to be obtained. We report a new that combines transverse scanning approach confocal laser ophthalmoscope with depth sectioning capability OCT. A stable high-frequency carrier generated by use an acousto optic modulator, and high frame rate obtained using resonant mirror priority (x-direction). Our prototype instrument records 64 images consisting 256x128 pixels in 1.2 seconds, thus providing fastest retinal 3D OCT system reported so far. demonstrate capabilities our measuring fovea nerve head region healthy human volunteers vivo.

参考文章(17)
R. Lattanzio, R. Brancato, L. Pierro, F. Bandello, B. Iaccheri, T. Fiore, G. Maestranzi, Macular thickness measured by optical coherence tomography (OCT) in diabetic patients. European Journal of Ophthalmology. ,vol. 12, pp. 482- 487 ,(2002) , 10.1177/112067210201200606
Henrik Lund-Andersen, Michael Larsen, Birgit Sander, Charlotte Strøm, Nicolai Larsen, Nicolai Larsen, Diabetic macular edema assessed with optical coherence tomography and stereo fundus photography. Investigative Ophthalmology & Visual Science. ,vol. 43, pp. 241- 245 ,(2002)
A.F. Fercher, C.K. Hitzenberger, Chapter 4 Optical coherence tomography Progress in Optics. ,vol. 44, pp. 215- 302 ,(2002) , 10.1016/S0079-6638(02)80017-8
Pascale Massin, Graham Duguid, Ali Erginay, Belkacem Haouchine, Alain Gaudric, Optical coherence tomography for evaluating diabetic macular edema before and after vitrectomy. American Journal of Ophthalmology. ,vol. 135, pp. 169- 177 ,(2003) , 10.1016/S0002-9394(02)01837-8
Robert H. Webb, George W. Hughes, Francois C. Delori, Confocal scanning laser ophthalmoscope Applied Optics. ,vol. 26, pp. 1492- 1499 ,(1987) , 10.1364/AO.26.001492
S A Boppart, B E Bouma, C Pitris, G J Tearney, J F Southern, M E Brezinski, J G Fujimoto, Intraoperative assessment of microsurgery with three-dimensional optical coherence tomography. Radiology. ,vol. 208, pp. 81- 86 ,(1998) , 10.1148/RADIOLOGY.208.1.9646796
F. I. Feldchtein, G. V. Gelikonov, V. M. Gelikonov, R. R. Iksanov, R. V. Kuranov, A. M. Sergeev, N. D. Gladkova, M. N. Ourutina, J. A. Warren, D. H. Reitze, In vivo OCT imaging of hard and soft tissue of the oral cavity Optics Express. ,vol. 3, pp. 239- 250 ,(1998) , 10.1364/OE.3.000239
Adrian Gh. Podoleanu, TRANSVERSAL AND LONGITUDINAL IMAGES FROM THE RETINA OF THE LIVING EYE USING LOW COHERENCE REFLECTOMETRY Journal of Biomedical Optics. ,vol. 3, pp. 12- 20 ,(1998) , 10.1117/1.429859
Barbara M. Hoeling, Andrew D. Fernandez, Richard C. Haskell, Eric Huang, Whittier R. Myers, Daniel C. Petersen, Sharon E. Ungersma, Ruye Wang, Mary E. Williams, Scott E. Fraser, An optical coherence microscope for 3-dimensional imaging in developmental biology Optics Express. ,vol. 6, pp. 136- 146 ,(2000) , 10.1364/OE.6.000136
Hsing-Wen Wang, Andrew M. Rollins, Joseph A. Izatt, High-speed full-field optical coherence microscopy Proceedings of the 1999 Coherence Domain Optical Methods in Biomedical Science and Clinical Applications III. ,vol. 3598, pp. 204- 212 ,(1999) , 10.1117/12.347491