Rac1 and Cdc42 Play Important Roles in Arsenic Neurotoxicity in Primary Cultured Rat Cerebellar Astrocytes.

摘要: This study aimed to explore whether Rac1 and Cdc42, representative members of Ras homologue guanosine triphosphatases (Rho GTPases), are involved in neurotoxicity induced by arsenic exposure rat nervous system. Expressions Cdc42 cerebellum cerebrum exposed different doses NaAsO2 (Wistar rats drank 0, 2, 10, 50 mg/L water for 3 months) were examined. Both expressions increased significantly a dose-dependent manner (P < 0.01) Western blot immunohistochemistry assay, but cerebrum, only 2 groups higher than those control 0.01). Five μM decreased cell viability primary cultured astrocytes, whereas 1 the these cells. inhibitor, NSC23766, NaAsO2-induced apoptosis cerebellar astrocytes 30 NaAsO2. ZCL278, cells Taken together, our current studies vivo vitro indicate that activations play very important role cerebellum, providing new insight into neurotoxicity.