Induction of Enzymes by Glucocorticoids and Catecholamines in a Rat Glial Cell Line

摘要: The rat brain glial tumor cell line RGC6 was originally selected for its high content of S100, a nervous tissue-specific protein (Benda et al., 1968). Subsequently, this shown to have retained other characteristic properties tissue, such as the glycerol phosphate dehydrogenase induction by Cortisol (de Vellis and Inglish, 1969). Although not all tissues been tested, appears be specific In addition, de Inglish found that catecholamines induced lactic in cells but several lines 1969; 1971b) Catecholamines, we shall see later, also cause large increase intracellular concentration cyclic AMP. magnitude response unique which has highest level adenylcyclase phosphodiesterase (for review, Robison 1971). function AMP system remains largely speculative. More generally, role hormones acquisition maintenance differention functions tissue is still far from being understood Clemente, 1970). chapter, will discuss target glucocorticoids catecholamines, rather opportunity contrast mechanisms action these two same line. Furthermore, studies hormonal factors and, course, S100 may provide insights into cells, are essentially unknown except oligodendrocytes Schwann myelination axons.