Environment-responsive aza-BODIPY dyes quenching in water as potential probes to visualize the in vivo fate of lipid-based nanocarriers

作者: Xiongwei Hu , Jian Zhang , Zhou Yu , Yunchang Xie , Haisheng He

DOI: 10.1016/J.NANO.2015.06.013

关键词: In vivoSolid lipid nanoparticleBODIPYBiochemistryFluorescenceDrug deliveryMicelleQuenching (fluorescence)NanocarriersMaterials science

摘要: Abstract Environment-responsive near-infrared (NIR) aza-BODIPY dyes capable of fluorescence quenching in water were explored to visualize the vivo fate model lipid-based nanocarriers, solid lipid nanoparticles (SLNs). The water-quenching effect was confirmed be sensitive and remained stable for at least 24h. In vitro lipolysis measured by completed within 20min, which correlation with alkaline compensation results. live imaging indicated predominant digestion SLNs 2h complete 4h, correlated well data. Rekindling quenched mixed micelles observed , but not . sharp contrast, encapsulating another NIR dye DiR showed persistent both despite significant lipolysis. It envisaged that can used as probes monitor nanocarriers. From Clinical Editor Lipid-based drug delivery systems provide an excellent nanocarrier platform poorly water-soluble drugs. Nonetheless, mechanism oral absorption subsequent kinetics is understood. this article, authors studied novel use these positive finding means approach may useful in-vivo monitoring

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