The influence of N-dialkyl and other cationic substituents on DNA intercalation and genotoxicity.

摘要: DNA intercalation by small chemical molecules can result in frameshift mutagenesis and chromosomal breakage. With evidence mounting that broadly diverse structures are capable of intercalating between base pairs, it becomes important to better define those structural features enhance strength confer genotoxicity particularly among intercalators do not have the classical planar tricyclic fused ring structure. A substituent is present on many pharmaceutical other biologically active N-dialkyl group. In study, we investigate if how presence an aromatic or cationic group affects ability 26 selected acridines, phenothiazines, benzophenones, triphenylethylenes classes molecules. The data were obtained from literature, experiments using a cell-based assay, modeling studies three-dimensional computational docking program. It demonstrated substitution both electrostatic interactions within chemical/DNA complex.