Cytogenetic effects of amitriptyline hydrochloride in somatic and germ cells of mice.
作者： P.Sadhana Chowdary , M.Sanjeeva Rao
DOI: 10.1016/0378-4274(87)90233-5
关键词:
摘要: Amitriptyline hydrochloride, an antidepressant drug, was tested in mice for mutagenic effects the somatic cells by micronucleus test and germ air drying technique of Evans et al. Mice were treated orally with drug at a dose 70, 140 210 mg/kg body weight. The results indicate that is capable inducing mutations both mitotic meiotic mice.
sci-hub.se 参考文章(14)
Aleksandrovskiĭ IuA, Filippova Lm, Shapiro IuL, Rapoport Ia, Mutagenic activity of psychotropic drugs Genetika. ,vol. 11, pp. 77- 82 ,(1975)
D. R. Paterson, The Causation of the Double First Cardiac Sound BMJ. ,vol. 2, pp. 45- 45 ,(1896) , 10.1136/BMJ.2.1853.45-B
E.P. Evans, G. Breckon, C.E. Ford, AN AIR-DRYING METHOD FOR MEIOTIC PREPARATIONS FROM MAMMALIAN TESTES. Cytogenetic and Genome Research. ,vol. 3, pp. 289- 294 ,(1964) , 10.1159/000129818
J.M. Robson, F.M. Sullivan, THE PRODUCTION OF FŒTAL ABNORMALITIES IN RABBITS BY IMIPRAMINE The Lancet. ,vol. 281, pp. 638- 639 ,(1963) , 10.1016/S0140-6736(63)91276-5
G. Singer, I. R. Coyle, The effect of imipramine administered before and during pregnancy on litter size in the rat. Psychopharmacology. ,vol. 32, pp. 337- 342 ,(1973) , 10.1007/BF00429469
E.F. Oakberg, A new concept of spermatogonial stem-cell renewal in the mouse and its relationship to genetic effects Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. ,vol. 11, pp. 1- 7 ,(1971) , 10.1016/0027-5107(71)90027-3
S.H. Gilani, Imipramine and Congenital Abnormalities Pathobiology. ,vol. 40, pp. 37- 42 ,(1974) , 10.1159/000162498
W. Schmid, The micronucleus test. Mutation Research\/environmental Mutagenesis and Related Subjects. ,vol. 31, pp. 9- 15 ,(1975) , 10.1016/0165-1161(75)90058-8
Tsu-Ker Fu, Lissy F. Jarvik, The in vitro effects of imipramine on human chromosomes. Mutation Research. ,vol. 48, pp. 89- 94 ,(1977) , 10.1016/0027-5107(77)90192-0
Eugene F. Oakberg, Duration of spermatogenesis in the mouse and timing of stages of the cycle of the seminiferous epithelium American Journal of Anatomy. ,vol. 99, pp. 507- 516 ,(1956) , 10.1002/AJA.1000990307