Psychotropics and Male Reproduction.

摘要: Psychotropic drugs, including antidepressants, antipsychotics, and anticonvulsants, all have negative effects on sexual function semen quality. These adverse events vary among men are less pronounced for some medications, allowing their to be managed extent. Use of specific serotonin reuptake inhibitors (SSRIs) is prevalent in reproductive age; application treat premature ejaculation increases the number young SSRI therapy. Oxidative damage sperm can result from prolonged residence male tract. The increase ejaculatory latency seen with SSRIs likely underlies quality, higher DNA fragmentation, evaluated thus far. medications prolactin (PRL) levels men, this often credited inhibitory reproduction; however, testosterone generally normal, reducing likelihood direct HPG axis inhibition by PRL. tricyclic antidepressants also been shown PRL studies but not others. exception antidepressant clomipramine, which profoundly may depress Other modulating synaptic serotonin, norepinephrine, and/or dopamine toxicity similar SSRIs, most evaluated. In limited studies, norepinephrine-dopamine (NDRIs) agonist/reuptake (SARIs) had minimal side effects. Antipsychotic PRL, decrease testosterone, effects, dysfunction. greatest evidence chlorpromazine, haloperidol, reserpine, risperidone, thioridazine, aripiprazole clozapine. Remarkably few looked at antipsychotic an important knowledge gap pharmacology. Lithium LH decreases although informed studies. many used other indications, free or bioavailable variable hormones. Valproate, carbamazepine, oxcarbazepine, levetiracetam quality; anticonvulsants investigated reaction. Studies required evaluating endpoints pregnancy offspring health psychotropic medications.