The effect of different treatments for early-lactation hyperketonemia on blood β-hydroxybutyrate, plasma nonesterified fatty acids, glucose, insulin, and glucagon in dairy cattle

摘要: Despite increased efforts in preventing the occurrence of metabolic disorders transition cows, hyperketonemia remains a frequent early-lactation disease affecting an average 40% cows herds United States. demonstrated economic effect this disorder, controlled clinical trials comparing different treatment strategies affected are lacking. The objective our study was to investigate with intravenous glucose, oral propylene glycol, or combination both on reduction blood β-hydroxybutyrate (BHB) concentrations hyperketonemic dairy cows. Multiparous Holstein between 3 9 d milk were screened for using handheld meter times per week, and enrolled at whole BHB concentration ≥1.2 mmol/L 1 4 groups: (1) 500 mL 50% dextrose solution i.v. once daily (GLU, n = 9), (2) 300 glycol as drench (PG, (3) orally (GLU+PG, 8), (4) untreated control group (CTRL, 8). Blood samples collected immediately before well 1, 2, 4, 8, 12, 24, 36, 48, 60, 72 h after administration first through jugular catheter week thereafter from coccygeal vessels. Concentrations measured blood, plasma analyzed fatty acid (NEFA), insulin, glucagon, electrolyte concentrations. EDTA-anticoagulated assessed red cell indices, smears made evaluation morphology. Outcomes repeated measures analysis. Overall least squares means (95% CI) 11 relative 1.11 (0.95 1.30), 1.26 (1.07 1.47), 0.96 (0.81 1.13), 1.53 (1.30 1.80) GLU, PG, GLU+PG, CTRL groups, respectively. Treatment glucose led greater magnitude more prolonged decrease compared individual treatments. NEFA glucagon lower GLU GLU+PG groups CTRL, associated increase insulin alone. Treatments did not lead differences mineral We conclude that treatments varied decreasing postpartum greatest decline glycol.