A panel of a mitogenic (PDGF), biochemical (albumin) and demographic (age) parameters for the non-invasive assessment of hepatic fibrosis.
作者： AM Attallah , MS Albannan , MM Omran , R Zayed , S Saif
DOI: 10.1080/09674845.2019.1600325
关键词: Albumin 、 Hepatitis C virus 、 Hepatic fibrosis 、 Gastroenterology 、 Medicine 、 Liver function tests 、 Platelet-derived growth factor receptor 、 Hepatic stellate cell 、 Internal medicine 、 Biomarker (medicine) 、 Fibrosis
摘要: Background: Several studies have investigated certain fibrosis markers that incorporate liver function tests, fragments of liver-matrix components and/or degraded products generated by hepatic stellate cells for determining the degree fibrosis. However, role these molecules in development is unclear. This work aimed (a) to determine whether platelet-derived growth factor (PDGF) linked different stages and (b) investigate its diagnostic performance alongside other laboratory demographic factors assessing chronic hepatitis C infection. Methods: Liver-fibrosis was staged according Fibroscan, PDGF quantified using ELISA, tests analytes determined standard techniques 239 patients with virus Results: Patients significant (F2-F4), advanced (F3-F4) cirrhotic disease (F4) showed significantly (P<0.0001) higher levels increase respectively compared stage F0/1. We used this construct PARA-Index (PDGF/albumin ratio, age), which performed well hepatic-fibrosis AUCs 0.91, 0.87 0.86 identifying F2-F4, F3-F4 F4, respectively. Additionally, correlated strongly (r=0.65, P<0.0001) severity An elevated PARA-index provided odds ratios 21.0, 20.7 10.3 developing Conclusion: A panel mitogenic (PDGF), biochemical (albumin) demographical (age) parameters may improve liver-fibrosis staging a high accuracy those
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