Platelet-Derived Growth Factor C in Alcoholics

摘要: AIMS Platelet-derived growth factor (PDGF) promotes liver collagen deposition, acting on hepatic stellate cells. Despite this, low serum PDGF levels were reported in chronic hepatitis C or B infection, although some studies yield the opposite result. Since may be related not only to fibrosis but also with vascular, neuronal muscle disease, it is important analyze its behavior alcoholics. METHODS In total, 17 controls and 62 alcoholic patients consecutively admitted hospitalization unit of Internal Medicine Service included. We determined C, routine laboratory evaluation, tumor necrosis factor-α, interleukin (IL)-6 IL-8 malondialdehyde (MDA) levels. analyzed relationships between function, ethanol intake inflammatory reaction by both univariate multivariate analysis discern which variables depend on. RESULTS Serum significantly lower among (675 ± 466 pg/ml) than (1074 ± 337 pg/ml; Z = 3.70; P < 0.001), even cirrhotics (549 ± 412 vs 778 ± 487 non-cirrhotics; Z = 2.33; P = 0.02). showed a direct correlation prothrombin activity (ρ = 0.50; platelet count (ρ = 0.44; P < 0.001) inverse ones bilirubin (ρ = -0.39; P = 0.002), IL-6 (ρ = -0.33; P = 0.016), (ρ = -0.47; MDA (ρ = -0.44; P < 0.001). By analysis, independently PDGF. CONCLUSION PDGF-C are decreased alcoholics, especially cirrhotics. Multivariate discloses that