Update on Estimation of Kidney Function in Diabetic Kidney Disease

摘要: The American Diabetes Association recommends annual assessment of glomerular filtration rate (GFR) to screen for diabetic nephropathy. GFR is measured indirectly using markers that, ideally, are eliminated only by filtration. Measured GFR, although the gold standard, remains cumbersome and expensive. therefore routinely estimated creatinine and/or cystatin C clinical variables. In pediatrics, Schwartz creatinine-based equation most frequently used even though combined C-based equations demonstrate stronger agreement with GFR. adults, CKD Epidemiology Collaboration (CKD-EPI) accurate precise estimating equations. Despite recent advances, current estimates lack precision accuracy before chronic kidney disease stage 3 (GFR < 60 mL/min/1.73 m2). There an urgent need improve methods measuring this review, we examine literature data addressing measurement estimation in diabetes.