Cobalt nanoparticles coated with graphitic shells as localized radio frequency absorbers for cancer therapy

摘要: Graphitic carbon-coated ferromagnetic cobalt nanoparticles (C?Co-NPs) with diameters of around 7?nm and cubic crystalline structures were synthesized by catalytic chemical vapor deposition. X-ray diffraction x-ray photoelectron spectroscopy analysis indicated that the inside carbon shells preserved in metallic state. Fluorescence microscopy images Raman revealed effective penetrations C?Co-NPs through cellular plasma membrane cultured HeLa cells, both cytoplasm nucleus. Low radio frequency (RF) radiation 350 kHz induced localized heat into nanoparticles, which triggered killing a process was found to be dependent on RF application time nanoparticle concentration. When compared nanostructures such as single-wall nanotubes, these coated magnetic demonstrated higher specificity for absorption heating. DNA gel electrophoresis assays cells after treatment showed strong broadening fragmentation spectrum, further proved intense thermally damages nucleus disintegration, under exposure presence C?Co-NPs. The data presented this report indicate great potential new vivo tumor thermal ablation, bacteria killing, various other biomedical applications.