Comparative Biochemistry of Lipoxygenase Inhibitors

摘要: This chapter describes some studies on the mechanism of 5-lipoxygenase regulation and inhibition then presents an overview lipoxygenase inhibitors that are active against intact-cell, broken-cell, purifed enzymes from a variety sources. Although large number have been reported, many these rather nonselective. Some lack selectivity may result common by antioxidants redox regulation. It is, therefore, not sufficient to define specificity broken-cell enzymes. A truly diagnostic agent must be specific in cellular systems vivo utility defining role lipoxygenases pathophysiology.