Effects of baicalein and α-tocopherol on lipid peroxidation, free radical scavenging activity and 12-O-tetradecanoylphorbol acetate-induced ear edema
作者： Hara Hideaki , Sukamoto Takayuki , Ohtaka Hiroshi , Abe Kenichi , Tatumi Yoshio
DOI: 10.1016/0014-2999(92)90700-E
关键词:
摘要: Abstract The effects of baicalein, a flavonoid, and α-tocopherol (vitamin E) on lipid peroxidation in rat forebrain homogenates. free radical scavenging action against diphenyl-p-picrylhydrazyl (DPPH), 12-O-tetradecanoylphorbol acetate (TPA)-induced car edema mice were studied. Baicalein inhibited pcroxidation forcbrain homogenates, DPPH-induced TPA-induced ear as potently did quercetin nordihydroguaiaretic acid (NDGA), lipoxygenase inhibitor, more than BW755C, mixed cyclooxygenase inhibitor. Lipid also by α-tocopherol. Flavonc showed no reaction. These results suggest that may play an important role the pathogenesis mice.
elsevier.com
sci-hub.se 参考文章(38)
Thomas W. Kensler, Michael A. Trush, Inhibition of Phorbol Ester-stimulated Chemiluminescence in Human Polymorphonuclear Leukocytes by Retinoic Acid and 5,6-Epoxyretinoic Acid Cancer Research. ,vol. 41, pp. 216- 222 ,(1981)
Robert W. Egan, Paul H. Gale, Comparative Biochemistry of Lipoxygenase Inhibitors Springer, Boston, MA. pp. 593- 607 ,(1985) , 10.1007/978-1-4684-4946-4_57
A. Mellors, A.L. Tappel, The Inhibition of Mitochondrial Peroxidation by Ubiquinone and Ubiquinol Journal of Biological Chemistry. ,vol. 241, pp. 4353- 4356 ,(1966) , 10.1016/S0021-9258(18)99728-0
K Kogure, H Hara, Prevention of hippocampus neuronal damage in ischemic gerbils by a novel lipid peroxidation inhibitor (quinazoline derivative). Journal of Pharmacology and Experimental Therapeutics. ,vol. 255, pp. 906- 913 ,(1990)
A Janoff, W Troll, A Klassen, Local Vascular Changes Induced by the Cocarcinogen, Phorbol Myristate Acetate Cancer Research. ,vol. 30, pp. 2568- 2571 ,(1970)
David Ogden, David Colquhoun, Nd Alasdair Gibb, Ogden et al. reply Trends in Pharmacological Sciences. ,vol. 8, pp. 335- ,(1987) , 10.1016/0165-6147(87)90141-6
Chen Yuting, Zheng Rongliang, Jia Zhongjian, Ju Yong, Flavonoids as superoxide scavengers and antioxidants. Free Radical Biology and Medicine. ,vol. 9, pp. 19- 21 ,(1990) , 10.1016/0891-5849(90)90045-K
E. Agradi, A. Petroni, A. Socini, C. Galli, In vitro effects of synthetic antioxidants and vitamin E on arachidonic acid metabolism and thromboxane formation in human platelets and on platelet aggregation Prostaglandins. ,vol. 22, pp. 255- 266 ,(1981) , 10.1016/0090-6980(81)90040-X
Rao V. Panganamala, David G. Cornwell, The effects of vitamin E on arachidonic acid metabolism. Annals of the New York Academy of Sciences. ,vol. 393, pp. 376- 391 ,(1982) , 10.1111/J.1749-6632.1982.TB31277.X
M-A. MORONEY, M. J. ALCARAZ, R. A. FORDER, F. CAREY, J. R. S. HOULT, Selectivity of neutrophil 5-lipoxygenase and cyclo-oxygenase inhibition by an anti-inflammatory flavonoid glycoside and related aglycone flavonoids. Journal of Pharmacy and Pharmacology. ,vol. 40, pp. 787- 792 ,(2011) , 10.1111/J.2042-7158.1988.TB05173.X