Commonalities in immune modulation between mesenchymal stem cells (MSCs) and neural stem/precursor cells (NPCs)

摘要: Owing to their unique immunomodulatory properties, mesenchymal stem cells (MSCs) have been advocated as a potential therapy for numerous pathological conditions in which immune-mediated inflammatory reactions play crucial role, such autoimmune disorders, cerebrovascular diseases and tumours. Increasing evidence suggest that cells, other than MSCs, are also capable of immunomodulation. Neural stem/precursor (NPCs) among the first show properties nowadays represent one most studied promising cell subtype still uncurable acute chronic neurological disorders. Although ontogeny NPCs MSCs greatly diverges, mechanisms similar largely based on bystander (paracrine) effect through membrane-bound soluble mediators influence behavior host immune cells. This observation suggests existence core signature across different lineages shared signalling pathways between niche response likely mediate both NPC MSC effect.