Neural stem/progenitor cells induce conversion of encephalitogenic T cells into CD4+-CD25+- FOXP3+ regulatory T cells.
作者： Arshed Nazmi , Iqbal Mohamed Arif , Kallol Dutta , Kiran Kundu , Anirban Basu
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摘要: Abstract An immune role of neural stem/progenitor cells (NSPCs) has been proposed in many recent studies; however much still remains to be elucidated. In the current investigation, we report that NSPCs possess ability convert encephalitogenic T into CD4+-CD25+-FOXP3+ regulatory (Treg). Encephalitogenic and nonencephalitogenic isolated from sham Japanese encephalitis virus (JEV) infected animals were co-cultured with mouse NSPCs. Post co-culture, significant increase number Tregs was observed This increased conversion found dependent on direct contact between Neutralization TGF-β IFN-γ NSPC cultures abrogated this Tregs. Flow cytometric, quantitative RT-PCR, immunoblot analysis both revealed surface intracellular changes post co-culture. Co-stimulatory molecules (B7) ICAM-1 increase...
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